2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2417):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-90006S2
    5-Fluorouracil-15N2
    		Inhibitor 99.53%
    5-Fluorouracil-15N2 is the 15N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV.
    5-Fluorouracil-<sup>15</sup>N<sub>2</sub>
  • HY-W115186
    DMT-2'-OMe-Bz-C
    		99.52%
    DMT-2'-OMe-Bz-C is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    DMT-2'-OMe-Bz-C
  • HY-108060A
    Valopicitabine dihydrochloride
    		99.04%
    Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination.
    Valopicitabine dihydrochloride
  • HY-W013330
    3′-Deoxyguanosine
    3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a derivative of Guanosine (HY-N0097). 3′-Deoxyguanosine interacts with human purine nucleoside phosphorylase via hydrogen bonding with residues such as Glu201 and Asn243. 3′-Deoxyguanosine exhibits moderate displacement activity for [3H]-guanosine in rat meninges. 3′-Deoxyguanosine is useful for studying the mechanism of guanosine receptors and purine metabolism.
    3′-Deoxyguanosine
  • HY-155600
    5′-Guanylyl methylenediphosphonate sodium
    		99.00%
    5′-Guanylyl methylenediphosphonate (sodium) is a GTP analogue and a specific, competitive inhibitor of the GTP reaction in protein synthesis.
    5′-Guanylyl methylenediphosphonate sodium
  • HY-B1449S8
    Uridine-d2-1
    		98.47%
    Uridine-d2-1 is the deuterium labeled Uridine.
    Uridine-d<sub>2</sub>-1
  • HY-50071
    6-Amino-5-nitropyridin-2-one
    		Chemical
    6-Amino-5-nitropyridin-2-one is a pyridine base and used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine.
    6-Amino-5-nitropyridin-2-one
  • HY-W008552
    2-Iodoadenosine
    		99.21%
    2-Iodoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2-Iodoadenosine
  • HY-B0016S
    Capecitabine-d11
    		Inhibitor 99.90%
    Capecitabine-d11 is the deuterium labeled Capecitabine. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.
    Capecitabine-d<sub>11</sub>
  • HY-100709
    ZPCK
    		Inhibitor 99.0%
    ZPCK is an oral active proagent of gemcitabine that was designed for improved oral bioavailability.
    ZPCK
  • HY-111648
    6-O-Methyl Guanosine
    		99.65%
    6-O-Methyl Guanosine is a Ribonucleoside. Replacement of the conserved G5, G8 or G12 residues in hammerhead ribozymes with 6-O-Methyl Guanosine reduces kcat without altering Km. 6-O-Methyl Guanosine exerts position-dependent regulatory effects on ribosomal velocity and fidelity. When 6-O-Methyl Guanosine is located at the first or third position of a codon, it decreases the accuracy of tRNA selection. When 6-O-Methyl Guanosine is located at the second position of a codon, it slows down the peptide bond formation rate of cognate aminoacyl-tRNA but does not change the reaction rate of near-cognate aminoacyl-tRNA.
    6-O-Methyl Guanosine
  • HY-130805
    5-Hydroxyuridine
    		98.94%
    5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Hydroxyuridine
  • HY-13538A
    Gemcitabine elaidate hydrochloride
    		Inhibitor
    Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity.
    Gemcitabine elaidate hydrochloride
  • HY-W009234
    6-Chloroguanineriboside
    		98.02%
    6-Chloroguanineriboside (6-Chloroguanosine) is a purine nucleoside analog. 6-Chloroguanineriboside has extremely low affinity for guanosine binding sites in rat brain (Ki: 253.1 μM).
    6-Chloroguanineriboside
  • HY-B0016R
    Capecitabine (Standard)
    		Inhibitor
    Capecitabine (Standard) is the analytical standard of Capecitabine. This product is intended for research and analytical applications. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.
    Capecitabine (Standard)
  • HY-135780A
    3'-Deoxyuridine-5'-triphosphate trisodium
    		≥98.0%
    3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM.
    3'-Deoxyuridine-5'-triphosphate trisodium
  • HY-138615S2
    Deoxythymidine-5'-triphosphate-13C10 dilithium
    		99.1%
    Deoxythymidine-5'-triphosphate-13C10 (dTTP-13C10) dilithium is 13C-labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.
    Deoxythymidine-5'-triphosphate-<sup>13</sup>C<sub>10</sub> dilithium
  • HY-W130204
    N-Acetyl-2′-deoxycytidine
    		99.59%
    N-Acetyl-2′-deoxycytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N-Acetyl-2′-deoxycytidine
  • HY-152334
    2’-Chloro-2’-deoxyadenosine
    		98.53%
    2’-Chloro-2’-deoxyadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Chloro-2’-deoxyadenosine
  • HY-122524AR
    7-Methylguanosine iodide (Standard)
    		Inhibitor
    7-Methylguanosine iodide (Standard) is the analytical standard of 7-Methylguanosine iodide (HY-122524AS). This product is intended for research and analytical applications. 7-Methylguanosine iodide is an iodide of 7-Methylguanosine (HY-122524). 7-Methylguanosine is a modified nucleoside widely present in various RNAs and a key metabolite of the 5'-cap structure of eukaryotic mRNA. 7-Methylguanosine plays important roles in stabilizing RNA structures, regulating translation, and other aspects.
    7-Methylguanosine iodide (Standard)